4-Chloroaniline → HCID 178489314, compound

HRID 1618585Notes

Reaction equation

HRID 1618585 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[CH3:9][O:10][C:11]1[CH:24]=[CH:23][CH:22]=[CH:21][C:12]=1[C:13]([CH2:15][C:16](OCC)=[O:17])=O>>[Cl:1][C:2]1[CH:8]=[C:7]2[C:5](=[CH:4][CH:3]=1)[N:6]=[C:13]([C:12]1[CH:21]=[CH:22][CH:23]=[CH:24][C:11]=1[O:10][CH3:9])[CH:15]=[C:16]2[OH:17]

Participants

3

Reactant 2

HCID 78124-ChloroanilineHCID 2759695Ethyl (2-methoxybenzoyl)acetate

Product 1

HCID 178489314HCID 178489314, compound

Procedure

Prepared according to procedure R using 4-chloroaniline (774.0 mg, 6.1 mmol), ethyl (2-methoxybenzoyl)acetate (2.0 mL, 10.3 mmol), and PPA (4.70 g, 47.0 mmol) to afford 6-chloro-2-(2-methoxyphenyl)quinolin-4-ol. Mass Spectrum (ESI) m/e=286.0 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-7c3f9b59b30741ee9eb6034fc9151dbb
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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