4-Chloroaniline → HCID 178427869, compound

HRID 1618604Notes

Reaction equation

HRID 1618604 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[F:9][C:10]([F:21])([F:20])[C:11](=O)[CH:12]([CH3:18])[C:13](OCC)=[O:14]>>[Cl:1][C:2]1[CH:8]=[C:7]2[C:5](=[CH:4][CH:3]=1)[N:6]=[C:11]([C:10]([F:21])([F:20])[F:9])[C:12]([CH3:18])=[C:13]2[OH:14]

Participants

3

Reactant 2

HCID 78124-ChloroanilineHCID 2737204Ethyl 2-methyl-4,4,4-trifluoroacetoacetate

Product 1

HCID 178427869HCID 178427869, compound

Procedure

Prepared according to procedure R using 4-chloroaniline (6.44 g, 50.47 mmol) and ethyl 4,4,4-trifluoro-2-methyl-3-oxobutanoate (10 g, 50.47 mmol) to give 6-chloro-3-methyl-2-(trifluoromethyl)quinolin-4-ol as an off-white solid: Mass Spectrum (ESI) m/e=262.0 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d444e1bd62e1464193fd19873f4905c7
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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