Phosphorus oxychloride → 4-Chloro-2,3,8-trimethylquinoline

HRID 1618628Notes

Reaction equation

HRID 1618628 reaction equation
[CH3:1][C:2]1[C:11]([CH3:12])=[C:10](O)[C:9]2[C:4](=[C:5]([CH3:14])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.O=P(Cl)(Cl)[Cl:17]>>[Cl:17][C:10]1[C:9]2[C:4](=[C:5]([CH3:14])[CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]([CH3:1])[C:11]=1[CH3:12]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178432146HCID 178432146, compound

Product 1

HCID 160906094-Chloro-2,3,8-trimethylquinoline

Procedure

Prepared according to procedure S using 2,3,8-trimethylquinolin-4-ol (1.7 g, 9.1 mmol) in POCl3 (12.5 mL, 136 mmol). The resulting precipitate was collected by filtration to give 4-chloro-2,3,8-trimethylquinoline. Mass Spectrum (ESI) m/e=206 (M+1).

Workup

  1. customPrepared
  2. filtrationThe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-15aebe77614b490a98531649b3df46f5
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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