Ethyl 2-methylacetoacetate → HCID 178432245, compound

HRID 1618630Notes

Reaction equation

HRID 1618630 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[CH3:9][CH:10]([C:16](=O)[CH3:17])[C:11](OCC)=[O:12]>>[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:3]=1[N:4]=[C:16]([CH3:17])[C:10]([CH3:9])=[C:11]2[OH:12]

Participants

3

Reactant 2

HCID 701Ethyl 2-methylacetoacetateHCID 72402-Chloroaniline

Product 1

HCID 178432245HCID 178432245, compound

Procedure

Prepared according to R using 2-chloroaniline (1.28 mL, 10 mmol) and ethyl 2-methyl-3-oxobutanoate (2.89 g, 20 mmol) in PPA (4 g, 40 mmol). The resulting precipitate was collected by filtration, washed with water, and dried to give 8-chloro-2,3-dimethylquinolin-4-ol as an off white solid. Mass Spectrum (ESI) m/e=208 (M+1).

Workup

  1. customPrepared
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-db46f3d526a544069b72cca72c1fc865
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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