Ethyl 2-methylacetoacetate → HCID 178432245, compound

Participants

Reaction Steps

Prepared according to R using 2-chloroaniline (1.28 mL, 10 mmol) and ethyl 2-methyl-3-oxobutanoate (2.89 g, 20 mmol) in PPA (4 g, 40 mmol). The resulting precipitate was collected by filtration, washed with water, and dried to give 8-chloro-2,3-dimethylquinolin-4-ol as an off white solid. Mass Spectrum (ESI) m/e=208 (M+1).

Provenance & Evidence