Phosphorus oxychloride → HCID 67284901, compound

HRID 1618633Notes

Reaction equation

HRID 1618633 reaction equation
[CH3:1][C:2]1[C:11]([CH3:12])=[C:10](O)[C:9]2[C:4](=[C:5]([C:14]([F:17])([F:16])[F:15])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.O=P(Cl)(Cl)[Cl:20]>>[Cl:20][C:10]1[C:9]2[C:4](=[C:5]([C:14]([F:17])([F:16])[F:15])[CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]([CH3:1])[C:11]=1[CH3:12]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178432239HCID 178432239, compound

Product 1

HCID 67284901HCID 67284901, compound

Procedure

Prepared according to procedure S using 2,3-dimethyl-8-(trifluoromethyl)-quinolin-4-ol (1.25 g, 5.18 mmol) in POCl3 (7 mL). The resulting precipitate was collected by filtration to give 4-chloro-2,3-dimethyl-8-(trifluoromethyl)quinoline. Mass Spectrum (ESI) m/e=260 (M+1).

Workup

  1. customPrepared
  2. filtrationThe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-8ddfeca74afe46378f5891022ab84b81
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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