反应详情

A solution of 6-bromo-1H-indole-3-carbonitrile (0.5 g, 2.26 mmol), 4,6-dichloro-2,3-dimethylquinoline (0.56 g, 2.49 mmol) and cesium carbonate (2.21 h, 6.79 mmol) in DMF (11.2 mL) was heated at 140° C. overnight. After this time the solvent was evaporated in vacuo and the residue was purified by flash column chromatography to give 6-bromo-1-(6-chloro-2,3-dimethylquinolin-4-yl)-1H-indole-3-carbonitrile as white solid. Mass Spectrum (ESI) m/e=411 (M+1).

1. customAfter this time the solvent was evaporated in vacuo
2. customthe residue was purified by flash column chromatography