HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-2-(tributylstannyl)pyridine → 4-Chloro-3-methyl-2-(4-methylpyridin-2-yl)-1,8-naphthyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-2-(tributylstannyl)pyridine | HCID 11222775 | — |
| Reactant | 2,4-Dichloro-3-methyl-1,8-naphthyridine | HCID 22082661 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 4-Chloro-3-methyl-2-(4-methylpyridin-2-yl)-1,8-naphthyridine | HCID 67284618 | — |
Reaction Steps
Prepared according to procedure E and using 2,4-dichloro-3-methyl-1,8-naphthyridine (500 mg, 2.347 mmol), 4-methyl-2-(tributylstannyl)pyridine (897 mg, 2.347 mmol) and Pd(PPh3)4 (271 mg, 0.235 mmol). Purification by column chromatography (hexanes:EtOAc, from 1:0 to 1:2) gave 4-chloro-3-methyl-2-(4-methylpyridin-2-yl)-1,8-naphthyridine. Mass Spectrum (ESI) m/e=270.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765940B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-e0d06df1a2e94b2781d34f1a7318b0f7 |
| Source note | uspto-grants-2014_07 |