4-Methyl-2-(tributylstannyl)pyridine → 4-Chloro-3-methyl-2-(4-methylpyridin-2-yl)-1,7-naphthyridine

Participants

Role	Name	HCID	Charge
Reactant	4-Methyl-2-(tributylstannyl)pyridine	HCID 11222775	—
Reactant	2,4-Dichloro-3-methyl-1,7-naphthyridine	HCID 59631549	—
Catalyst	HCID 178418397	HCID 178418397	—
Product	4-Chloro-3-methyl-2-(4-methylpyridin-2-yl)-1,7-naphthyridine	HCID 67285050	—

Reaction Steps

Prepared according to procedure E using 2,4-dichloro-3-methyl-1,7-naphthyridine (100 mg, 0.469 mmol), 4-methyl-2-(tributylstannyl)pyridine (215 mg, 0.563 mmol) and Pd(PPh3)4 (54.2 mg, 0.047 mmol). After purification 4-chloro-3-methyl-2-(4-methylpyridin-2-yl)-1,7-naphthyridine was obtained as a white solid. Mass Spectrum (ESI) m/e=270.0 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08765940B2
Source dataset	uspto-grants-2014_07
ORD ID	ord-79ddae6a4f974053aaea7bca08987452
Source note	uspto-grants-2014_07