反应详情

11.9 g (60.0 mmol) of 12-dodecanolide and 24.3 g (96.0 mmol, 1.6 equivalents) of a 32% (hydrogen bromide)/(acetic acid) solution were introduced into a 100-mL autoclave protected with Teflon (registered trademark), and the autoclave was purged with nitrogen and then sealed. The content in the autoclave was stirred with a magnetic stirrer for 16 hours by using an oil bath at 60° C. After cooling the mixture, 14 mL of water was added thereto, and the mixture was transferred into a separatory funnel by using 200 mL of hot hexane. The mixture was washed with ion-exchanged water, dried over magnesium sulfate, filtered, and crystallized from n-hexane. Thus, 14.4 g (yield: 86%) of 12-bromododecanoic acid was obtained.

1. customthe autoclave was purged with nitrogen
2. customsealed
3. customat 60° C
4. temperatureAfter cooling the mixture, 14 mL of water
5. additionwas added
6. customthe mixture was transferred into a separatory funnel
7. washThe mixture was washed with ion-exchanged water
8. dry with materialdried over magnesium sulfate
9. filtrationfiltered
10. customcrystallized from n-hexane