Phenylephrine Hydrochloride → Phenylephrine

Participants

Reaction Steps

2125.0 g of phenylephrine hydrochloride was dissolved in 2000.0 g of deionized water in a suitable stainless steel container. 2500.0 g of Amberlite IRP-69 ion exchange resin, commercially available from Rohm & Haas Corporation, was added thereto and stirred using a laboratory mixer at 100 RPM for at least 12 hours. The resulting slurry was filtered through a Wattman #4 filter paper using vacuum filtration. The resulting solid was air dried for 1-2 hours to yield wet resin particles, which were then dried in a Glatt fluid bed GPCG-1 drier for 10 minutes at 50° C. The resulting dry particles contained approximately 32.0% phenylephrine. The remaining, unbound phenylephrine remained in the filtered slurry solution.

Provenance & Evidence