(-)-Phenylephrine hydrochloride → Phenylephrine

HRID 1618817Notes

Reaction equation

HRID 1618817 reaction equation
[CH3:1][NH:2][CH2:3][C@H:4]([OH:12])[C:5]1[CH:6]=[CH:7][CH:8]=[C:9]([OH:11])[CH:10]=1.Cl>O>[CH3:1][NH:2][CH2:3][C@H:4]([OH:12])[C:5]1[CH:6]=[CH:7][CH:8]=[C:9]([OH:11])[CH:10]=1

Participants

3

Reactant 1

HCID 5284443(-)-Phenylephrine hydrochloride

Product 1

HCID 6041Phenylephrine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2125.0 g of phenylephrine hydrochloride was dissolved in 2000.0 g of deionized water in a suitable stainless steel container. 2500.0 g of Amberlite IRP-69 ion exchange resin, commercially available from Rohm & Haas Corporation, was added thereto and stirred using a laboratory mixer at 100 RPM for at least 12 hours. The resulting slurry was filtered through a Wattman #4 filter paper using vacuum filtration. The resulting solid was air dried for 1-2 hours to yield wet resin particles, which were then dried in a Glatt fluid bed GPCG-1 drier for 10 minutes at 50° C. The resulting dry particles contained approximately 32.0% phenylephrine. The remaining, unbound phenylephrine remained in the filtered slurry solution.

Workup

  1. addition2500.0 g of Amberlite IRP-69 ion exchange resin, commercially available from Rohm & Haas Corporation, was added
  2. customfor at least 12 hours
  3. filtrationThe resulting slurry was filtered through a Wattman #4
  4. filtrationfilter paper
  5. filtrationvacuum filtration
  6. customdried for 1-2 hours
  7. customto yield wet resin particles, which
  8. customwere then dried in a Glatt fluid bed GPCG-1 drier for 10 minutes at 50° C
  9. customThe resulting dry particles

Sources & evidence

ORD record
ord-2b057ee7ef93493f836a917c985ab926
Source dataset
uspto-grants-2014_07
Patent number
US08771716B2

Reaction notes

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