Trifluoroacetic acid → HCID 86691462, compound

HRID 1618865Notes

Reaction equation

[CH:1](=[C:3]1[C:7]([C:14]2[CH:15]=[C:16]([CH:32]=[CH:33][CH:34]=2)[O:17][CH2:18][C:19]([NH:21][CH2:22][CH2:23][NH:24]C(=O)OC(C)(C)C)=[O:20])([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:6][CH:5]([CH3:35])[N:4]1[CH3:36])[CH3:2].[F:37][C:38]([F:43])([F:42])[C:39]([OH:41])=[O:40]>ClCCl>[F:37][C:38]([F:43])([F:42])[C:39]([OH:41])=[O:40].[NH2:24][CH2:23][CH2:22][NH:21][C:19](=[O:20])[CH2:18][O:17][C:16]1[CH:32]=[CH:33][CH:34]=[C:14]([C:7]2([C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH2:6][CH:5]([CH3:35])[N:4]([CH3:36])[C:3]2=[CH:1][CH3:2])[CH:15]=1

Participants

Conditions

Temperature: 25 °C

Procedure

Product of Step 12 (0.13 g) was dissolved in dichloromethane (10 mL). To this, trifluoroacetic acid (2.5 mL) was added and the reaction mixture was stirred at 25° C. for 1 hr. The reaction mixture was evaporated under vacuum to obtain Step 13 product (0.1 g), which was carried forward without further purification.

Workup

customThe reaction mixture was evaporated under vacuum

Sources & evidence

ORD record: ord-bf03ccf4e2254a619d06546fbaf11eed
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08771964B2

Reaction notes

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