反应详情

To a solution of 1-(5-Acetyl-1H-pyrrol-3-yl)-2,2,2-trichloro-ethanone (0.980 g, 3.85 mmol) in ethanol (10 mL), potassium carbonate (0.224 g, 1.62 mmol) was added and the mixture refluxed for 1 h. The mixture was cooled at room temperature and filtred through a celite pad washing with ethanol (50 mL). Organic solvent was evaporated to dryness and the residue dissolved in ethylacetate (15 mL) and washed with water (2×10 mL) and brine (5 mL), dried over sodium sulfate, filtered, and concentered in vacuo to give 0.567 g (81%) of the title compound as a white solid.

1. temperaturethe mixture refluxed for 1 h
2. washwashing with ethanol (50 mL)
3. customOrganic solvent was evaporated to dryness
4. dissolutionthe residue dissolved in ethylacetate (15 mL)
5. washwashed with water (2×10 mL) and brine (5 mL)
6. dry with materialdried over sodium sulfate
7. filtrationfiltered