1-Ethynyl-3-fluorobenzene → HCID 136038173, compound

HRID 1619292Notes

Reaction equation

HRID 1619292 reaction equation
Br[C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:12])[NH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[CH:16]=1)#[CH:14]>>[F:21][C:17]1[CH:16]=[C:15]([C:13]#[C:14][C:2]2[CH:11]=[C:10]3[C:5]([C:6](=[O:12])[NH:7][CH:8]=[N:9]3)=[CH:4][CH:3]=2)[CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 5202181-Ethynyl-3-fluorobenzeneHCID 1355556127-Bromo-3,4-dihydroquinazolin-4-one

Product 1

HCID 136038173HCID 136038173, compound

Procedure

The title compound was prepared from 7-bromoquinazolin-4(3H)-one and 1-ethynyl-3-fluorobenzene according to the experimental procedure as described in Example 1.1. MS (ESI): 265 (MH+); 1H NMR (300 MHz, DMSO-d6) δ 12.37 (s, 1H), 8.14 (s, 2H), 7.83 (s, 1H), 7.68-7.64 (m, 1H), 7.53-7.49 (m, 3H), 7.36-7.33 (m, 1H). mGluR5 PAM EC50: +.

Sources & evidence

ORD record
ord-e3a0c284051d415191e8171a247f93ce
Source dataset
uspto-grants-2014_07
Patent number
US08772301B2

Reaction notes

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