Methylamine → HCID 58574688, compound

HRID 1619306Notes

Reaction equation

HRID 1619306 reaction equation
C1(S(O[CH2:11][CH:12]2[N:24]3[C:15](=[N:16][C:17]4[CH:18]=[C:19]([Br:26])[CH:20]=[CH:21][C:22]=4[C:23]3=[O:25])[CH2:14][CH2:13]2)(=O)=O)C=CC=CC=1.[CH3:27][NH2:28]>C(#N)C>[Br:26][C:19]1[CH:20]=[CH:21][C:22]2[C:23](=[O:25])[N:24]3[CH:12]([CH2:11][NH:28][CH3:27])[CH2:13][CH2:14][C:15]3=[N:16][C:17]=2[CH:18]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 58574766HCID 58574766, compound

Product 1

HCID 58574688HCID 58574688, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
60 °C

Procedure

To the solution of (6-bromo-9-oxo-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-1-yl)methyl benzenesulfonate (100 mg, 0.23 mmol) in acetonitrile (4 mL) was added aq. methylamine (2 mL). The reaction mixture was stirred at 60° C. for 4 h. After concentration, the crude product was purified by column chromatography to give the desired product. MS (ESI): 308, 310 (MH+).

Workup

  1. concentrationAfter concentration
  2. customthe crude product was purified by column chromatography

Sources & evidence

ORD record
ord-0f2e5ffb7e2045ef91a5a706cb687f07
Source dataset
uspto-grants-2014_07
Patent number
US08772301B2

Reaction notes

Loading…