Trifluoroacetic acid → HCID 58574251, compound

HRID 1619325Notes

Reaction equation

HRID 1619325 reaction equation
[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1([CH3:19])[CH2:11][CH2:10][CH2:9][N:8]1C(OC(C)(C)C)=O)=[O:4].C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1([CH3:19])[CH2:11][CH2:10][CH2:9][NH:8]1)=[O:4]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58574532HCID 58574532, compound

Product 1

HCID 58574251HCID 58574251, compoundYield 32.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl 2-((2-chloroacetamido)methyl)-2-methylpyrrolidine-1-carboxylate (0.7 g, 4.8 mmol) and TFA (3 mL) in DCM was stirred at room temperature for about 3 h. Then the solution was concentrated to give 300 mg of the crude product, which was directly used for the next step. MS (ESI): 191, 193 (MH+).

Workup

  1. concentrationThen the solution was concentrated

Sources & evidence

ORD record
ord-d5fb570cca26452f99e9ecac9abc4429
Source dataset
uspto-grants-2014_07
Patent number
US08772301B2

Reaction notes

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