Hydrogen Peroxide → HCID 67257607, compound

HRID 1619329Notes

Reaction equation

HRID 1619329 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](=[O:12])C(=O)[NH:8]2)=[C:4]([F:13])[CH:3]=1.[OH:14]O>[OH-].[Na+]>[NH2:8][C:9]1[CH:10]=[C:2]([Br:1])[CH:3]=[C:4]([F:13])[C:5]=1[C:6]([OH:12])=[O:14]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 672585381312454-85-5

Product 1

HCID 67257607HCID 67257607, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

To a solution of 6-bromo-4-fluoroindoline-2,3-dione (7.4 g, 31.8 mmol) in 1 M NaOH (100 mL) was added 38% H2O2 (13 mL) dropwise. The resulting solution was stirred at rt for 2 h. The mixture was filtered and the filtrate was acidified using hydrochloric acid (2 N) till pH became around 2. The precipitate was formed and filtered, washed with water, dried under vacuum to give 2.8 g of the desired product. MS (ESI): 232, 234 (MH−).

Workup

  1. filtrationThe mixture was filtered
  2. customThe precipitate was formed
  3. filtrationfiltered
  4. washwashed with water
  5. customdried under vacuum

Sources & evidence

ORD record
ord-f322590bfeb841a2a8db703f119164dd
Source dataset
uspto-grants-2014_07
Patent number
US08772301B2

Reaction notes

Loading…