反应详情

To a solution of azepan-2-one (0.5 g, 4.42 mmol, 1 equiv) in anhydrous THF (20 mL) under nitrogen, was added n-BuLi (4.4 mL, 2.5 M in n-hexane, 11.06 mmol) dropwise at 0° C. The reaction mixture was kept at 0° C. for 2 h, then MeI (0.3 mL, 4.86 mmol) was added. After stirring for 1 h, the mixture was quenched with water and extracted with DCM (2×50 mL). The combined organic layers were dried over anhydrous Na2SO4. After filtration and concentration, the crude product was directly used for the next step without further purification. MS (ESI): 128 (MH+).

1. customthe mixture was quenched with water
2. extractionextracted with DCM (2×50 mL)
3. dry with materialThe combined organic layers were dried over anhydrous Na2SO4
4. filtrationAfter filtration and concentration
5. customthe crude product was directly used for the next step without further purification