HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Azepan-4-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-tert-Butyl 4-ethyl 5-oxoazepane-1,4-dicarboxylate | HCID 4436570 | — |
| Product | Azepan-4-one hydrochloride | HCID 22021728 | — |
Reaction Steps
A solution of 1-tert-butyl 4-ethyl 5-oxoazepane-1,4-dicarboxylate (0.9 g, 3.16 mmol, 1 equiv) in aq. HCl (30 mL, 4N) was stirred at reflux for 7 h. The reaction mixture was then concentrated to give the desired product, which was directly used for the next step without further purification. MS (ESI): 114 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772301B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-46666af3e61245eba19b69c3cfc8d166 |
| Source note | uspto-grants-2014_07 |