Hydrochloric Acid → Azepan-4-one hydrochloride

HRID 1619371Notes

Reaction equation

HRID 1619371 reaction equation
[O:1]=[C:2]1[CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][CH2:4][CH:3]1C(OCC)=O.[ClH:21]>>[ClH:21].[NH:6]1[CH2:5][CH2:4][CH2:3][C:2](=[O:1])[CH2:8][CH2:7]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 44365701-tert-Butyl 4-ethyl 5-oxoazepane-1,4-dicarboxylate

Product 1

HCID 22021728Azepan-4-one hydrochloride

Procedure

A solution of 1-tert-butyl 4-ethyl 5-oxoazepane-1,4-dicarboxylate (0.9 g, 3.16 mmol, 1 equiv) in aq. HCl (30 mL, 4N) was stirred at reflux for 7 h. The reaction mixture was then concentrated to give the desired product, which was directly used for the next step without further purification. MS (ESI): 114 (MH+).

Workup

  1. temperatureat reflux for 7 h
  2. concentrationThe reaction mixture was then concentrated

Sources & evidence

ORD record
ord-46666af3e61245eba19b69c3cfc8d166
Source dataset
uspto-grants-2014_07
Patent number
US08772301B2

Reaction notes

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