Triethylamine → HCID 58574192, compound

HRID 1619374Notes

Reaction equation

HRID 1619374 reaction equation
C(=O)([O-])[O:2][C:3](C1C2C=CC=CC=2C2C1=CC=CC=2)(C)[CH:4]1[N:8]2[C:9](=[O:18])[C:10]3[N:16]=[CH:15][C:14]([Br:17])=[CH:13][C:11]=3[N:12]=[C:7]2[CH2:6][CH2:5]1.CCN(CC)CC>C(Cl)Cl>[OH:2][CH2:3][CH:4]1[N:8]2[C:9](=[O:18])[C:10]3[N:16]=[CH:15][C:14]([Br:17])=[CH:13][C:11]=3[N:12]=[C:7]2[CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 86762497HCID 86762497, compound

Product 1

HCID 58574192HCID 58574192, compoundYield 43.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (9H-fluoren-9-yl)methyl(3-bromo-10-oxo-6,7,8,10-tetrahydropyrido[3,2-d]pyrrolo[1,2-a]pyrimidin-8-yl)methyl carbonate (1.4 g, 4.7 mmol) in DCM (50 mL) was added Et3N (4 mL). The mixture was stirred for 5 h at room temperature. The reaction mixture was then concentrated and purified by column chromatography to give 0.6 g of the desired product. MS (ESI): 296, 298 (MH+).

Workup

  1. concentrationThe reaction mixture was then concentrated
  2. custompurified by column chromatography

Sources & evidence

ORD record
ord-38d9872dc14547d9a35c9fd839fa5ff9
Source dataset
uspto-grants-2014_07
Patent number
US08772301B2

Reaction notes

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