Ethyl 3-(1-Boc-2-pyrrolidinyl)acrylate → HCID 58574582, compound

HRID 1619396Notes

Reaction equation

HRID 1619396 reaction equation
[CH2:1]([O:3][C:4](=[O:19])[CH:5]=[CH:6][CH:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH3:2].[H][H]>CO.[Pd]>[CH2:1]([O:3][C:4](=[O:19])[CH2:5][CH2:6][CH:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH3:2]

Participants

5

Reactant 2

HCID 53933727Ethyl 3-(1-Boc-2-pyrrolidinyl)acrylateHCID 178418361HCID 178418361, compound

Product 1

HCID 58574582HCID 58574582, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of tert-butyl 2-(3-ethoxy-3-oxoprop-1-enyl)pyrrolidine-1-carboxylate (4 g, 14.9 mmol) and Pd/C (1 g, 10% weight) in MeOH was stirred at room temperature. Hydrogen from a balloon was ventilated to the suspension continuously and the completion of the reaction was monitored by TLC. After the suspension was filtered, the organic phases was concentrated to give the desired product, which was directly used for the next step without further purification. MS (ESI): 272 (MH+).

Workup

  1. filtrationAfter the suspension was filtered
  2. concentrationthe organic phases was concentrated

Sources & evidence

ORD record
ord-48a5ca7c2295432caba5ed11de7dbd2a
Source dataset
uspto-grants-2014_07
Patent number
US08772301B2

Reaction notes

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