4-Bromo-2-(carboxymethyl)benzoic acid → 6-Bromoisochroman-1,3-dione

HRID 1619402Notes

Reaction equation

HRID 1619402 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([CH2:11][C:12]([OH:14])=[O:13])[CH:3]=1>C(OC(=O)C)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:9][CH:10]=1)[C:6](=[O:8])[O:14][C:12](=[O:13])[CH2:11]2

Participants

3

Reactant 1

HCID 534401324-Bromo-2-(carboxymethyl)benzoic acid

Product 1

HCID 217824866-Bromoisochroman-1,3-dione

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A solution of 4-bromo-2-carboxymethyl-benzoic acid (200 mg, 1.1 mmol) in 2 mL acetic anhydride was refluxed for 10 h. Then the mixture was concentrated to dryness and the crude 6-bromoisochroman-1,3-dione was used into the next step without further purification.

Workup

  1. concentrationThen the mixture was concentrated to dryness
  2. customthe crude 6-bromoisochroman-1,3-dione was used into the next step without further purification

Sources & evidence

ORD record
ord-2b197f55248443d384a2191fd12cdeb9
Source dataset
uspto-grants-2014_07
Patent number
US08772301B2

Reaction notes

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