Thionyl Chloride → HCID 58574194, compound

HRID 1619413Notes

Reaction equation

HRID 1619413 reaction equation
[CH3:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][C:7]([C:13]([OH:15])=O)=[CH:8][CH:9]=2)[N:4]=[CH:3]1.O=S(Cl)[Cl:18]>>[CH3:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][C:7]([C:13]([Cl:18])=[O:15])=[CH:8][CH:9]=2)[N:4]=[CH:3]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 280651823-Methyl-4-oxo-3,4-dihydroquinazoline-7-carboxylic acid

Product 1

HCID 58574194HCID 58574194, compound

Procedure

A solution of 3-methyl-4-oxo-3,4-dihydroquinazoline-7-carboxylic acid (110 mg, 0.54 mmol) in SOCl2 (8 mL) was stirred at reflux for 5 h. The excess SOCl2 was then removed under reduced pressure. The crude 3-methyl-4-oxo-3,4-dihydroquinazoline-7-carbonyl chloride was used without further purification for the next step.

Workup

  1. temperatureat reflux for 5 h
  2. customThe excess SOCl2 was then removed under reduced pressure
  3. customThe crude 3-methyl-4-oxo-3,4-dihydroquinazoline-7-carbonyl chloride was used without further purification for the next step

Sources & evidence

ORD record
ord-2b2fc54978ef445085f81ea818a6fa78
Source dataset
uspto-grants-2014_07
Patent number
US08772301B2

Reaction notes

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