反应详情

A solution of (E)-7-methoxy-4-methyl-3,4,5,6-tetrahydro-2H-azepine (1.1 g) and 2-aminoterephthalic acid (1.4 g, 7.7 mmol) in DMF (30 mL) was stirred at 100° C. for 4 h. After it was cooled to room temperature, the reaction was diluted with water (80 mL) and extracted with ethyl acetate (2×60 mL). The combined organic layers were washed with brine and dried over anhydrous sodium sulfate. After filtration and concentration, the crude product was purified by silica gel chromatography to give 47 mg of desired product.

1. extractionextracted with ethyl acetate (2×60 mL)
2. washThe combined organic layers were washed with brine
3. dry with materialdried over anhydrous sodium sulfate
4. filtrationAfter filtration and concentration
5. customthe crude product was purified by silica gel chromatography