反应详情

温度

30 °C

To a solution of diethyl 2-(4-(benzyloxy)phenyl)malonate (20 gm, 0.0585 mole) in ethanol (200 ml) was added sodium borohydride (17.4 gm, 0.4678 mole) in portions at 0° C. and the reaction mixture was stirred for 4 hrs at 30° C. The reaction mixture was poured into ice cold water, acidified with conc. HCl and extracted with ethyl acetate. The organic extract was successively washed with water & brine, dried over sodium sulfate and concentrated under reduced pressure to provide 14.5 gm of product as white solid.

1. additionThe reaction mixture was poured into ice cold water
2. extractionextracted with ethyl acetate
3. extractionThe organic extract
4. washwas successively washed with water & brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated under reduced pressure