反应详情

温度

30 °C

To a suspension of 2-(4-(benzyloxy)phenyl)propane-1,3-diol (2.0 gm, 0.00775 moles) in dry toluene (500 ml), dry acetone (20 ml) and PTSA (1.2 gm, 0.0062 mole) were added and the reaction mixture was stirred for 18 hours at 30° C. The reaction mixture was poured into ice cold water and extracted with ethyl acetate. The organic extract was washed successively with water & brine, dried over sodium sulfate and evaporated under reduced pressure to yield 1.47 gm product as white solid.

1. additionwere added
2. additionThe reaction mixture was poured into ice cold water
3. extractionextracted with ethyl acetate
4. extractionThe organic extract
5. washwas washed successively with water & brine
6. dry with materialdried over sodium sulfate
7. customevaporated under reduced pressure