4-((4-(2,2-Dimethyl-1,3-dioxan-5-yl)phenoxy)methyl)-2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazole → 2-(4-((2-(1-(Pyrimidin-2-yl)piperidin-4-yl)thiazol-4-yl)methoxy)phenyl)propane-1,3-diol

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-((4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)methyl)-2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazole (500 mg, 0.0010 moles) in acetone (20 ml), conc. HCl (2 ml) was added portion-wise and the reaction mixture was stirred for 12 hours at 27° C. The reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The organic layer was successively washed with water & brine, dried over sodium sulfate and evaporated under reduced pressure to yield 500 mg product as white solid

Provenance & Evidence