反应详情

温度

27 °C

To a solution of 4-((4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)methyl)-2-(1-(pyrimidin-2-yl)piperidin-4-yl)thiazole (500 mg, 0.0010 moles) in acetone (20 ml), conc. HCl (2 ml) was added portion-wise and the reaction mixture was stirred for 12 hours at 27° C. The reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The organic layer was successively washed with water & brine, dried over sodium sulfate and evaporated under reduced pressure to yield 500 mg product as white solid

1. concentrationThe reaction mixture was concentrated
2. dissolutionthe residue was dissolved in ethyl acetate
3. washThe organic layer was successively washed with water & brine
4. dry with materialdried over sodium sulfate
5. customevaporated under reduced pressure