Hydrochloric Acid → HCID 68296696, compound

HRID 1619455Notes

Reaction equation

HRID 1619455 reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([NH:15]C(=O)C)=[CH:10][C:9]=2Br)=[O:5])C.[ClH:20].[CH2:21]([OH:23])C>>[ClH:20].[NH2:15][C:11]1[CH:12]=[C:13]2[C:8](=[C:9]([O:23][CH3:21])[CH:10]=1)[NH:7][C:6]([C:4]([OH:3])=[O:5])=[CH:14]2

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 68296563HCID 68296563, compound

Product 1

HCID 68296696HCID 68296696, compound

Procedure

A mixture of 982 mg I.19 (5-acetylamino-7-bromo-1H-indole-2-carboxylic acid ethyl ester), 10 ml ethanol and 1.8 ml concentrated hydrochloric acid was stirred for 4.5 h at reflux. The reaction mixture was evaporated. The residue was used in the next step without purification.

Workup

  1. temperatureat reflux
  2. customThe reaction mixture was evaporated
  3. customThe residue was used in the next step without purification

Sources & evidence

ORD record
ord-47540f3fdea04208870265db3997e6ad
Source dataset
uspto-grants-2014_07
Patent number
US08772305B2

Reaction notes

Loading…