Water → HCID 11300149, compound

HRID 1619476Notes

Reaction equation

HRID 1619476 reaction equation
[CH2:1]([N:5]1[C:17]2[CH:16]=[N:15][C:14]([C:18]([O:20]CC)=[O:19])=[CH:13][C:12]=2[C:11]2[C:6]1=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:2][CH2:3][CH3:4].O.[OH-].[Na+].O(C1C=C2C(C3C=CN=C(C)C=3N2CC)=CC=1)C>C(O)C>[CH2:1]([N:5]1[C:17]2[CH:16]=[N:15][C:14]([C:18]([OH:20])=[O:19])=[CH:13][C:12]=2[C:11]2[C:6]1=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:2][CH2:3][CH3:4]

Participants

6

Reactant 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 486623HCID 486623, compoundHCID 16092376HCID 16092376, compound

Product 1

HCID 11300149HCID 11300149, compoundYield 100.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Compound 32 (3.0 g, 10 mmol), 100 ml of water, 50 ml of ethanol, and NaOH (2.0 g, 50 mmol) were added into a 100 ml round-bottom flask. The mixture was refluxed for 2 h. The subsequent operational steps were conducted according to those for synthesizing compound 3 to obtain light yellow solids (2.7 g, 99%), and mp 182-184° C.

Workup

  1. temperatureThe mixture was refluxed for 2 h

Sources & evidence

ORD record
ord-bc261a7630944d658475bb6d7c60af98
Source dataset
uspto-grants-2014_07
Patent number
US08772311B2

Reaction notes

Loading…