(+/-)-{3-Chloro-6-[(4-fluoro-benzenesulfonyl)-methyl-amino]-5,6,7,8-tetrahydro-2,4b-diaza-fluoren-9-yl}-acetic acid → HCID 59471427, compound

HRID 1619492Notes

Reaction equation

HRID 1619492 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5]2[C:6]([CH2:27][C:28]([OH:30])=[O:29])=[C:7]3[N:12]([C:13]=2[CH:14]=1)[CH2:11][CH:10]([N:15]([S:17]([C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=1)(=[O:19])=[O:18])[CH3:16])[CH2:9][CH2:8]3>CO.[Pd]>[F:26][C:23]1[CH:22]=[CH:21][C:20]([S:17]([N:15]([CH3:16])[CH:10]2[CH2:9][CH2:8][C:7]3[N:12]([C:4]4[N:3]=[CH:2][CH:14]=[CH:13][C:5]=4[C:6]=3[CH2:27][C:28]([OH:30])=[O:29])[CH2:11]2)(=[O:18])=[O:19])=[CH:25][CH:24]=1

Participants

4

Reactant 1

HCID 59471435(+/-)-{3-Chloro-6-[(4-fluoro-benzenesulfonyl)-methyl-amino]-5,6,7,8-tetrahydro-2,4b-diaza-fluoren-9-yl}-acetic acid

Product 1

HCID 59471427HCID 59471427, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of (±)-{3-chloro-6-[(4-fluoro-benzenesulfonyl)-methyl-amino]-5,6,7,8-tetrahydro-2,4b-diaza-fluoren-9-yl}-acetic acid (2 mg) and 2 mg of Pd/C (20%) in 0.5 mL of MeOH was stirred under Hz (balloon pressure) for 8 h. The suspension was filtered through celite and the filtrate was concentrated to give the title compound. MS (ES): 418.0 (M+1).

Workup

  1. filtrationThe suspension was filtered through celite
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-7eb4671d6461496d98519a9149d9a41c
Source dataset
uspto-grants-2014_07
Patent number
US08772312B2

Reaction notes

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