反应详情

2-Chloro-1-phenylethanone (30.0 mg, 0.19 mmol) was added to a solution of (R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-phenylacetate (C1) (70.0 mg, 0.19 mmol) in EtOAc (2 ml). The reaction was stirred at RT for 24 hours. Then Et2O (1 ml) was added, and the reaction was sonicated. The solid was collected by suction filtration to obtain (3R)-3-(2-(tert-butoxycarbonylamino)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride (54.6 mg; 55% yield).

1. customthe reaction was sonicated
2. filtrationThe solid was collected by suction filtration