反应详情

5-Chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-pyrimidin-2-yl-benzenesulfonamide (Preparation 13, 216 mg, 0.47 mmol), 3-pyridazin-4-yl-4′-(trifluoromethyl)biphenyl-4-ol (Preparation 8, 150 mg, 0.47 mmol) and potassium carbonate (196 mg, 1.42 mmol) were stirred in dimethylsulfoxide (3 mL) at room temperature for 18 hours. A 1M aqueous solution of sodium hydroxide was added to the reaction mixture whereupon a precipitate was observed. The precipitate was collected by filtration and dissolved in ethyl acetate. The ethyl acetate was dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo to afford the title compound as a solid (357 mg, 100%).

1. filtrationThe precipitate was collected by filtration
2. dissolutiondissolved in ethyl acetate
3. dry with materialThe ethyl acetate was dried over anhydrous magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated in vacuo