Acetyl chloride → (R)-3-methoxy-dihydro-furan-2,5-dione

HRID 1619926Notes

Reaction equation

HRID 1619926 reaction equation
[CH3:1][O:2][C@H:3]([CH2:7][C:8]([OH:10])=[O:9])[C:4]([OH:6])=O.C(Cl)(=O)C>>[CH3:1][O:2][C@@H:3]1[CH2:7][C:8](=[O:9])[O:10][C:4]1=[O:6]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 5325475(R)-methoxy-succinic acid

Product 1

HCID 86689062(R)-3-methoxy-dihydro-furan-2,5-dione

Procedure

260 mg (1.76 mmol) (R)-methoxy-succinic acid are stirred together with 5 ml acetyl chloride for 2 days at RT, then the acetyl chloride is eliminated by rotary evaporation in vacuo.

Workup

  1. customthe acetyl chloride is eliminated by rotary evaporation in vacuo

Sources & evidence

ORD record
ord-19823be922e347f4a76b1f5ab5467e58
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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