HCID 67461127, compound → 5-ethyl-6-[2-(4-hydroxy-phenyl)-benzoxazol-6-yl]-4,5-dihydro-2H-pyridazin-3-one

HRID 1619949Notes

Reaction equation

HRID 1619949 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[O:16][C:17]3[CH:23]=[C:22]([C:24]4[CH:25]([CH2:31][CH3:32])[CH2:26][C:27](=[O:30])[NH:28][N:29]=4)[CH:21]=[CH:20][C:18]=3[N:19]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>[Pd].CO>[CH2:31]([CH:25]1[C:24]([C:22]2[CH:21]=[CH:20][C:18]3[N:19]=[C:15]([C:12]4[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=4)[O:16][C:17]=3[CH:23]=2)=[N:29][NH:28][C:27](=[O:30])[CH2:26]1)[CH3:32]

Participants

5

Reactant 2

HCID 67461127HCID 67461127, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 1360889275-ethyl-6-[2-(4-hydroxy-phenyl)-benzoxazol-6-yl]-4,5-dihydro-2H-pyridazin-3-one

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

235 mg (552 μmol) 6-[2-(4-benzyloxy-phenyl)-benzoxazol-6-yl]-5-ethyl-4,5-dihydro-2H-pyridazin-3-one are hydrogenated together with 50 mg palladium on charcoal 10% and 50 ml of methanol at RT and 3.45 bar hydrogen pressure for 2.5 h, then the catalyst is filtered off and the filtrate is evaporated down completely i.V.

Workup

  1. filtrationthe catalyst is filtered off
  2. customthe filtrate is evaporated down completely i.V

Sources & evidence

ORD record
ord-4f079b54589e4b079d5ab6200d621bad
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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