Potassium Iodide → HCID 67467398, compound

HRID 1619952Notes

Reaction equation

HRID 1619952 reaction equation
[CH2:1]([CH:3]1[C:8]([C:9]2[CH:24]=[CH:23][C:12]3[N:13]=[C:14]([C:16]4[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=4)[O:15][C:11]=3[CH:10]=2)=[N:7][NH:6][C:5](=[O:25])[CH2:4]1)[CH3:2].Cl[CH2:27][C:28](=[O:30])[CH3:29].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CC(C)=O>[CH2:1]([CH:3]1[C:8]([C:9]2[CH:24]=[CH:23][C:12]3[N:13]=[C:14]([C:16]4[CH:21]=[CH:20][C:19]([O:22][CH2:27][C:28](=[O:30])[CH3:29])=[CH:18][CH:17]=4)[O:15][C:11]=3[CH:10]=2)=[N:7][NH:6][C:5](=[O:25])[CH2:4]1)[CH3:2]

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 6571ChloroacetoneHCID 11430Potassium CarbonateHCID 1360889275-ethyl-6-[2-(4-hydroxy-phenyl)-benzoxazol-6-yl]-4,5-dihydro-2H-pyridazin-3-one

Product 1

HCID 67467398HCID 67467398, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

100 mg (298 μmol) 5-ethyl-6-[2-(4-hydroxy-phenyl)-benzoxazol-6-yl]-4,5-dihydro-2H-pyridazin-3-one, 24 μL (301 μmol) chloroacetone, 83 mg (601 μmol) potassium carbonate, 50 mg (301 μmol) potassium iodide and 10 ml acetone are heated together at 60° C. overnight. Then the mixture is extracted with 10% sodium carbonate solution and EA. The org. phase is washed with sat. saline solution, dried on sodium sulphate and then the solv. is totally eliminated i.V. The residue is purified through silica gel (eluant: DCM/methanol)

Workup

  1. extractionThen the mixture is extracted with 10% sodium carbonate solution and EA
  2. washphase is washed with sat. saline solution
  3. customdried on sodium sulphate
  4. customThe residue is purified through silica gel (eluant: DCM/methanol)

Sources & evidence

ORD record
ord-7c1623544f6e4bf6b0bc24a003d35f6c
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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