2(3H)-Benzoxazolone → HCID 23160512, compound

HRID 1619962Notes

Reaction equation

HRID 1619962 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]1=[O:10].[Cl:11][CH:12]([CH3:16])[C:13](O)=[O:14]>>[Cl:11][CH:12]([CH3:16])[C:13]([C:7]1[CH:8]=[CH:9][C:4]2[NH:3][C:2](=[O:10])[O:1][C:5]=2[CH:6]=1)=[O:14]

Participants

3

Reactant 2

HCID 60432(3H)-BenzoxazoloneHCID 117342-Chloropropionic acid

Product 1

HCID 23160512HCID 23160512, compound

Procedure

81.1 g (600 mmol) 2-benzoxazolinone are dissolved at 80° C. in 720 g polyphosphoric acid. Then 66.1 ml (720 mmol) 2-chloropropionic acid are added dropwise and the mixture is heated for 3 h to 125° C., then the reaction mixture is poured onto ice water, the precipitated product is suction filtered, washed with water and dried at 98° C. in the circulating air dryer.

Workup

  1. temperaturethe mixture is heated for 3 h to 125° C.
  2. additionthe reaction mixture is poured onto ice water
  3. filtrationfiltered
  4. washwashed with water
  5. customdried at 98° C. in the circulating air dryer

Sources & evidence

ORD record
ord-ed443705c524410aba6c92fb80d2d2fd
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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