反应详情

温度

110 °C

While cooling with the ice bath 69.9 ml (1396 mmol) hydrazine hydrate are added dropwise to 220 ml glacial acetic acid, then 54.7 g (175 mmol) 4-(4-benzylamino-3-hydroxy-phenyl)-3-methyl-4-oxo-butyric acid are added and the mixture is stirred for 1.5 h at 110° C. Then the mixture is cooled somewhat and poured onto ice water, the precipitated product is suction filtered, washed first with copious amounts of water, then with a little acetone and then dried in the vacuum dryer.

1. temperatureThen the mixture is cooled somewhat
2. additionpoured onto ice water
3. filtrationfiltered
4. washwashed first with copious amounts of water
5. dry with materialwith a little acetone and then dried in the vacuum dryer