HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1619968Generated: November 1, 2026
Benzoic Acid → 5-methyl-6-(2-phenyl-benzoxazol-6-yl)-4,5-dihydro-2H-pyridazin-3-one
https://huagongshe.com/reaction/1619968
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzoic Acid | HCID 243 | — |
| Reactant | Trichloroacetonitrile | HCID 11011 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 6-(4-amino-3-hydroxy-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one | HCID 17993493 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5-methyl-6-(2-phenyl-benzoxazol-6-yl)-4,5-dihydro-2H-pyridazin-3-one | HCID 67462637 | — |
Reaction Steps
219 mg (1 mmol) 6-(4-amino-3-hydroxy-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one, 122 mg (1 mmol) benzoic acid, 1.7 g (3 mmol) polymer-bound triphenylphosphine, 289 mg (2 mmol) trichloroacetonitrile and 7.5 ml acetonitrile are placed in a microwave vial and heated to 120° C. for 15 min at 200 W. The resin is filtered off and washed with methanol as well as acetonitrile. The solv. is eliminated by rotary evaporation i.V. and the residue is purified by RP-HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08772323B2 |
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| Source dataset | uspto-grants-2014_07 |
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| ORD ID | ord-9e72acad523f46b080d0b437e1780aec |
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| Source note | uspto-grants-2014_07 |
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