2-(2-Hydroxyethoxy)ethanol;methoxymethane → 2-Ethyl-3-methyl-4-oxo-4-(2-phenyl-benzoxazol-6-yl)-butyric acid

HRID 1619985Notes

Reaction equation

HRID 1619985 reaction equation
[CH2:1]([C:3]([CH:10]([CH3:28])[C:11](=[O:27])[C:12]1[CH:26]=[CH:25][C:15]2[N:16]=[C:17]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[O:18][C:14]=2[CH:13]=1)(C(O)=O)[C:4]([OH:6])=[O:5])[CH3:2].C(O)COCCO.COC>O>[CH2:1]([CH:3]([CH:10]([CH3:28])[C:11](=[O:27])[C:12]1[CH:26]=[CH:25][C:15]2[N:16]=[C:17]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[O:18][C:14]=2[CH:13]=1)[C:4]([OH:6])=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 212256572-(2-Hydroxyethoxy)ethanol;methoxymethaneHCID 674631882-Ethyl-2-[1-methyl-2-oxo-2-(2-phenyl-benzoxazol-6-yl)-ethyl]-malonic acid

Product 1

HCID 674648492-Ethyl-3-methyl-4-oxo-4-(2-phenyl-benzoxazol-6-yl)-butyric acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

200 mg (524 μmol) 2-ethyl-2-[1-methyl-2-oxo-2-(2-phenyl-benzoxazol-6-yl)-ethyl]-malonic acid are heated together with 5 ml diethyleneglycol-dimethylether for 1 h at 140° C. in the microwave. The solv. is largely removed i.V., the residue is mixed with a little water and freeze-dried.

Workup

  1. customfreeze-dried

Sources & evidence

ORD record
ord-e8fee2b687454e68ae596400415c5cd4
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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