HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Hydroxyethoxy)ethanol;methoxymethane → 2-Ethyl-3-methyl-4-oxo-4-(2-phenyl-benzoxazol-6-yl)-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Hydroxyethoxy)ethanol;methoxymethane | HCID 21225657 | — |
| Reactant | 2-Ethyl-2-[1-methyl-2-oxo-2-(2-phenyl-benzoxazol-6-yl)-ethyl]-malonic acid | HCID 67463188 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Ethyl-3-methyl-4-oxo-4-(2-phenyl-benzoxazol-6-yl)-butyric acid | HCID 67464849 | — |
Reaction Steps
200 mg (524 μmol) 2-ethyl-2-[1-methyl-2-oxo-2-(2-phenyl-benzoxazol-6-yl)-ethyl]-malonic acid are heated together with 5 ml diethyleneglycol-dimethylether for 1 h at 140° C. in the microwave. The solv. is largely removed i.V., the residue is mixed with a little water and freeze-dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772323B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-e8fee2b687454e68ae596400415c5cd4 |
| Source note | uspto-grants-2014_07 |