(2-Thiophen-2-yl-benzoxazol-6-yl)methanol → 2-Thiophen-2-yl-benzoxazole-6-carbaldehyde

HRID 1619998Notes

Reaction equation

HRID 1619998 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[O:7][C:8]2[CH:14]=[C:13]([CH2:15][OH:16])[CH:12]=[CH:11][C:9]=2[N:10]=1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[O:7][C:8]2[CH:14]=[C:13]([CH:15]=[O:16])[CH:12]=[CH:11][C:9]=2[N:10]=1

Participants

4

Reactant 1

HCID 67466243(2-Thiophen-2-yl-benzoxazol-6-yl)methanol

Product 1

HCID 820366102-Thiophen-2-yl-benzoxazole-6-carbaldehyde

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

3.7 g (16.0 mmol) (2-thiophen-2-yl-benzoxazol-6-yl)-methanol are dissolved in 200 ml DCM, 15.0 g (10.78 mmol) manganese dioxide are added and the suspension is stirred overnight at RT. The next day the suspension is filtered through kieselguhr and the filtrate is concentrated completely by rotary evaporation i. V.

Workup

  1. filtrationThe next day the suspension is filtered through kieselguhr
  2. concentrationthe filtrate is concentrated completely by rotary evaporation i

Sources & evidence

ORD record
ord-6b136be23d0844fe8f7d4c78d963c661
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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