反应详情

A solution of 1.2 g (5.23 mmol) 2-thiophen-2-yl-benzoxazole-6-carbaldehyde and 2.5 g (11.06 mmol) ethyl (E)-3-iodoacrylate in DMSO is added dropwise at RT to 4.0 g (32.55 mmol) chromium-(II)-chloride and 10 mg (0.08 mmol) nickel-(II)-chloride. The reaction mixture is stirred overnight at RT, then combined with sat. ammonium chloride solution and extracted 3× with DCM. The combined org. phases are concentrated by rotary evaporation i. V. and the residue is purified on silica gel (eluant: cyclohexane/EA).

1. extractionextracted 3× with DCM
2. concentrationphases are concentrated by rotary evaporation i
3. customand the residue is purified on silica gel (eluant: cyclohexane/EA)