Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl 3-chlorothiophene-2-carboxylate | HCID 12993676 | — |
| Reactant | HCID 67467227 | HCID 67467227 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86689073 | HCID 86689073 | — |
Reaction Steps
100.0 mg (330 μmol) 2-amino-1-(2-phenyl-benzoxazol-6-yl)-propan-1-one as the hydrochloride are cooled to 0° C. together with 183.1 μl (1321 μmol) triethylamine and 3 ml THF, then 34.7 μl (333 μmol) ethyl chlorothiolformate are added dropwise. The mixture is stirred for 2 h at 0° C., then the reaction mixture is combined with DCM and extracted with water, the org. phase is dried on magnesium sulphate and the solv. is eliminated by rotary evaporation i. V.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08772323B2 |
|---|
| Source dataset | uspto-grants-2014_07 |
|---|
| ORD ID | ord-7360ccae783b4df8bf230a354ad75b68 |
|---|
| Source note | uspto-grants-2014_07 |
|---|
