Hydrochloric Acid → HCID 86689073, compound

HRID 1620001Notes

Reaction equation

[NH2:1][CH:2]([CH3:20])[C:3]([C:5]1[CH:19]=[CH:18][C:8]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[O:11][C:7]=2[CH:6]=1)=[O:4].Cl.C(N(CC)CC)C.Cl[C:30]1C=[CH:33][S:32][C:31]=1C(OCC)=O.C1C[O:43]CC1>C(Cl)Cl>[CH3:20][CH:2]([NH:1][C:33](=[O:43])[S:32][CH2:31][CH3:30])[C:3](=[O:4])[C:5]1[CH:19]=[CH:18][C:8]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[O:11][C:7]=2[CH:6]=1

Participants

Conditions

Temperature: 0 °C

Procedure

100.0 mg (330 μmol) 2-amino-1-(2-phenyl-benzoxazol-6-yl)-propan-1-one as the hydrochloride are cooled to 0° C. together with 183.1 μl (1321 μmol) triethylamine and 3 ml THF, then 34.7 μl (333 μmol) ethyl chlorothiolformate are added dropwise. The mixture is stirred for 2 h at 0° C., then the reaction mixture is combined with DCM and extracted with water, the org. phase is dried on magnesium sulphate and the solv. is eliminated by rotary evaporation i. V.

Workup

extractionextracted with water
customphase is dried on magnesium sulphate

Sources & evidence

ORD record: ord-7360ccae783b4df8bf230a354ad75b68
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08772323B2

Reaction notes

Loading…