Lawesson's reagent → HCID 86689074, compound

HRID 1620005Notes

Reaction equation

HRID 1620005 reaction equation
[C:1]([Si:5]([CH3:28])([CH3:27])[O:6][CH:7]([CH2:25][CH3:26])[C:8]([N:10]1[CH2:15][CH2:14][C:13]2[N:16]=[C:17]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[O:18][C:12]=2[CH2:11]1)=O)([CH3:4])([CH3:3])[CH3:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:38])=CC=1>C1(C)C=CC=CC=1>[C:1]([Si:5]([CH3:28])([CH3:27])[O:6][CH:7]([CH2:25][CH3:26])[C:8]([N:10]1[CH2:15][CH2:14][C:13]2[N:16]=[C:17]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[O:18][C:12]=2[CH2:11]1)=[S:38])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 67462713HCID 67462713, compound

Product 1

HCID 86689074HCID 86689074, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
90 °C

Procedure

680.00 mg (1.70 mmol) 2-(tert-butyl-dimethyl-silanyloxy)-1-(2-phenyl-6,7-dihydro-4H-oxazolo[5,4-c]pyridin-5-yl)-butan-1-one and 1.40 g (3.46 mmol) Lawesson's reagent are placed in 35 mL toluene and stirred overnight at 90° C. The solvent of the reaction mixture is eliminated in vacuo and the residue is purified on silica gel. (Eluant: cyclohexane/EA).

Workup

  1. customthe residue is purified on silica gel

Sources & evidence

ORD record
ord-77b26315285643c9b2649bc130c6a585
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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