Trifluoroacetic acid → HCID 86689075, compound

HRID 1620006Notes

Reaction equation

HRID 1620006 reaction equation
C([Si](C)(C)[O:6][CH:7]([CH2:25][CH3:26])[C:8]([N:10]1[CH2:15][CH2:14][C:13]2[N:16]=[C:17]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[O:18][C:12]=2[CH2:11]1)=[S:9])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[OH:6][CH:7]([CH2:25][CH3:26])[C:8]([N:10]1[CH2:15][CH2:14][C:13]2[N:16]=[C:17]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[O:18][C:12]=2[CH2:11]1)=[S:9]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86689074HCID 86689074, compound

Product 1

HCID 86689075HCID 86689075, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

310.00 mg (744 μmol) 2-(tert-butyl-dimethyl-silanyloxy)-1-(2-phenyl-6,7-dihydro-4H-oxazolo[5,4-c]pyridin-5-yl)-butan-1-thione are placed in 10 mL DCM, 2.50 mL TFA are added and the mixture is stirred for 4 h at RT. The solvent of the reaction mixture is eliminated in vacuo and the residue is purified on silica gel. (Eluant: cyclohexane/EA).

Workup

  1. customthe residue is purified on silica gel

Sources & evidence

ORD record
ord-2cf419c573ec419bbc2151960f7ca64a
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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