HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → {4-[6-(4-Ethyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-benzoxazol-2-yl]-phenoxy}-acetaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | HCID 67465409 | HCID 67465409 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | {4-[6-(4-Ethyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-benzoxazol-2-yl]-phenoxy}-acetaldehyde | HCID 86689077 | — |
Reaction Steps
22.2 mg (52 μmol) 6-{2-[4-(2,2-dimethoxy-ethoxy)-phenyl]-benzoxazol-6-yl}-5-ethyl-4,5-dihydro-2H-pyridazin-3-one, 130 μL (4 mmol/mL; 520 μmol) HCl and 2 ml dioxane are stirred for 3 h at 50° C. Then the mixture is diluted with EA, extracted with H2O and then with 10% sodium carbonate solution. The solv. of the org. phase is eliminated i.V.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772323B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-dfd884c16b2f48839117004cb81740ca |
| Source note | uspto-grants-2014_07 |